送交者: 寒露 于 June 06, 2010 21:56:31:
回答: 还是小说外的话题 由 Passer-By-From-Texas 于 June 06, 2010 16:34:57:
随便聊聊，就使大家受益匪浅，愿常随便聊聊：））
在PubMed上找到了你说的那篇文章，是2004年在JAMA上发表的 （JAMA. 2004 Feb 18;291(7):827-35. 标题：Antibiotic use in relation to the risk of breast cancer. 作者：Velicer CM, Heckbert SR, Lampe JW, Potter JD, Robertson CA, Taplin SH.单位：Department of Epidemiology, University of Washington, Seattle, USA），有意思的是，同时也看到一篇2006年的文章，不完全赞成上述观点，下面是摘要：
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2102-6.
Antibiotics and risk of breast cancer: up to 9 years of follow-up of 2.1 million women.
Friedman GD, Oestreicher N, Chan J, Quesenberry CP Jr, Udaltsova N, Habel LA.
Division of Research, Kaiser Permanente Medical Care Program, 2000 Broadway, Oakland, CA 94612, USA. gdf@dor.kaiser.org
Abstract
Antibiotic use has been associated with risk of breast cancer in previous reports. Using Cox proportional hazards analysis, we evaluated this association in 2,130,829 adult female subscribers of a health care program according to their receipt of prescriptions of antibiotics from outpatient pharmacies. Hormone use was taken into account. Altogether, 18,521 women developed breast cancer in up to 9.4 years of follow-up. Use of any antibiotic was associated with slightly increased risk [hazard ratio (HR), 1.14; 95% confidence interval (95% CI), 1.10-1.18] but there was little, if any, evidence of dose response, with HR of 1.17 (95% CI, 0.97-1.42) for >1,000 days of use compared with no use. The only two weakly associated antibiotic groups (HR >1.10 for >100 days of use) were tetracyclines and macrolides with HRs (95% CI) of 1.23 (1.11-1.36) and 1.16 (0.98-1.36), respectively. An association of lincosamides with breast cancer in an earlier, smaller database was not confirmed, but follow-up was too short in the present data for adequate evaluation. Medical record review suggested that acne and/or rosacea could be the underlying factor, associated with long-term antibiotic therapy and found by others to be associated with risk of breast cancer. Although causality cannot be ruled out, the observed associations of antibiotics overall, tetracyclines, and macrolides with breast cancer were weak and could be explained by uncontrolled confounding by the diseases being treated or by other factors.
按照现在（2009-2010年）的观点，breast cancer 的起因主要是激素（占发病率的70-80%）和遗传因素（百分之十几）以及少量的外来因素。如果antibiotic是一个因素的话，应该算做少量的外来因素。但是我赞成你的观点，antibiotic不能乱用、泛用，这一点，美国相对做的好一些。
开卷有益，讨论有益。
晚安！